Structural basis for the unique molecular properties of broad-range phospholipase C from Listeria monocytogenes
Abstract Listeriosis is one of the most serious foodborne diseases caused by the intracellular bacterium Listeria monocytogenes.Its two major virulence factors, broad-range phospholipase C (LmPC-PLC) and the pore-forming toxin listeriolysin O (LLO), enable the bacterium to spread in the host by destroying cell membranes.Here, we determine the cryst